Tuesday, November 22, 2011

Firefighters aided by easing winds in Reno fire (AP)

RENO, Nev. ? Aided by easing winds and spreading snow, firefighters advanced on a wildfire fueled by fierce gusts that sent nearly 10,000 people from their homes as it sparked blazes throughout an affluent community at Reno's edge.

Authorities said that the worst was likely over as growing flurries and falling temperatures stoked hopes that the remaining showers of ember and ash would die down.

The fire was blamed for the death of a 74-year-old man who had a heart attack while trying to flee. It also left a firefighter first- and second-degree burns and sent 16 people to hospitals, many for smoke inhalation.

Fire officials cited winds of up to 60 mph as a driving force of the northwestern Nevada fire early Friday that also destroyed or damaged up to 25 homes.

Reno Fire Chief Mike Hernandez said that firefighters made large advances against the blaze.

"The winds are laying down which is greatly improving our ability to manage the fire," he said just before sunset, adding that snowfall will also help extinguish hot spots.

But fire officials at an evening news conference weren't ready to declare victory.

"The threat to homes is still there," said fire spokesman Mike Regan. "There is still a lot of hot embers and dry fuel out there. We don't have a good established line around the fire."

More than 100 police officers and National Guard members were patrolling streets in the fire area to protect homes from vandals, Assistant Police Chief Mke Whan said.

The wind carried embers up to a mile, attacking upscale homes in random spurts. Police went house-to-house, pounding on doors and urging residents to evacuate in the dark of the night. Flames at times reached 50-feet high.

The cause of the blaze wasn't known, but a downed power line or homeless encampments in the area might be to blame, Hernandez said. He said the region is also a popular area for teenagers who might have started the fire to stay warm.

At least 400 firefighters from as far as 260 miles away flocked to Reno early Friday as multiple fires roared from the Sierra Nevada foothills in northwestern Nevada and spread to the valley floor.

The wind grounded firefighting helicopters and made it difficult for firefighters to approach Caughlin Ranch, the affluent subdivision bordering pine-forested hills where the fire likely began after 12:30 a.m. It also helped the fire spread from 400 acres to more than 3 square miles.

The gusts were comparable to the Santa Ana winds that often aggravate and spread wildfires in the hills surrounding Los Angeles, officials said.

"The wind is horrific," said Reno spokeswoman Michele Anderson. "We just watched a semi nearly blow over on the freeway."

Hernandez said residents ran from their homes dressed in pajamas, frantically trying to grab as many possessions as possible. One elderly man dressed in his underwear ran out with a blanket wrapped around his body.

Dick Hecht said that when he escaped from his home with his wife, "the whole mountain was on fire," and it was so windy he could barely stand.

"It was like a tornado," he said.

The couple tried to return to their home before morning, but they were turned back by high winds and erupting flames. As they made their way back down the mountain roads, flames burned less than 40 yards from their vehicle.

Evacuees could return to their homes at noon Saturday, Reno Mayor Bob Cashell said. A number of local hotel-casinos were also offering discounted rooms to displaced residents.

More than 150 people had filled two shelters set up at area high schools by midmorning.

John and Maggie Givlin were among those watching a television at Reno High School, scanning the screen for details on whether the home they left behind was safe. They already were preparing to flee when a police officer knocked on their door at about 1:30 a.m.

"I looked out the front window and saw the glow over the hill before us," John Givlin said.

He and his wife made their way out of their home with a flashlight. Outside, flames billowed in every direction.

A number of local hotel-casinos offered discounted rooms to displaced residents and at least 90 schools were closed for the day to clear the roads of school traffic and make way for emergency workers.

More than 4,000 NV Energy customers lost power as poles and electrical wires were scorched and knocked down, said spokeswoman Faye Andersen. Utility workers were not allowed into the fire area.

The U.S. Postal Service suspended delivery to the area for the day, and the state high school athletic association moved its football playoffs from Friday night to Monday.

___

Associated Press writers Martin Griffith in Reno; a and Michelle Rindels, Cristina Silva and Ken Ritter in Las Vegas contributed to this report.

Source: http://us.rd.yahoo.com/dailynews/rss/topstories/*http%3A//news.yahoo.com/s/ap/20111119/ap_on_re_us/us_reno_fire

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Monday, November 21, 2011

Poor recycling of BACE1 enzyme could promote Alzheimer's disease

Monday, November 21, 2011

Sluggish recycling of a protein-slicing enzyme could promote Alzheimer's disease, according to a study published online on November 21 in The Journal of Cell Biology (www.jcb.org).

Abeta, the toxic protein that accumulates in the brains of Alzheimer's patients, is formed when enzymes cut up its parental protein, known as amyloid precursor protein. One of those enzymes is beta-secretase or BACE1. BACE1 cycles between the Golgi apparatus and the plasma membrane, traveling through endosomes on the way. A protein complex called the retromer helps transport proteins back from endosomes to the Golgi. Previous studies have found reduced levels of two retromer components, including the protein VPS35, in the brains of patients with Alzheimer's disease.

To find out whether VPS35 affects Alzheimer's disease progression, Wen-Cheng Xiong and colleagues crossed two mouse lines to create animals that are prone to many symptoms of the disease and generate half the normal amount of VPS35. The mice displayed Alzheimer's-like abnormalities earlier than their parental strains, and their brains accumulated more Abeta.

Cells lacking VPS35 carried extra BACE1 in their endosomes, consistent with a defect in retromer-mediated protein transport. BACE1 is more active in the acidic interior of endosomes than in the more basic surroundings of the Golgi apparatus. Thus, by leaving more BACE1 trapped in endosomes, the decline in VPS35 levels could enhance BACE1 activity and generate more Abeta. Although no VPS35 mutations have so far turned up in Alzheimer's patients, the protein's level in the brain dwindles in aging mice. The researchers suspect that certain Alzheimer's disease risk factors, such as oxidative stress, also diminish VPS35 levels in the brain.

###

Rockefeller University Press: http://www.rupress.org/

Thanks to Rockefeller University Press for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/115359/Poor_recycling_of_BACE__enzyme_could_promote_Alzheimer_s_disease_

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NYC mayor: Manhattan man arrested in bomb plot (AP)

NEW YORK ? Mayor Michael Bloomberg says an al-Qaida sympathizer who plotted to bomb police and post offices in New York City has been arrested.

Bloomberg announced Sunday the arrest of 27-year-old Jose Pimentel on numerous charges.

Pimentel was arrested Saturday. He is accused of having an explosive substance that he planned to use against others and property to terrorize the public.

The New York Police Department's Intelligence Division was involved in the arrest.

___

Associated Press writer Colleen Long contributed to this report from New York.

Source: http://us.rd.yahoo.com/dailynews/rss/topstories/*http%3A//news.yahoo.com/s/ap/20111121/ap_on_re_us/us_nyc_bomb_plot

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Deficit supercommittee on brink of failure

By Andrew Taylor?
The Associated Press

Updated?at 2 p.m. ET

On the brink of failure, members of a special deficit-cutting committee blamed each other Sunday for the intransigence that has gridlocked the panel in its quest to cut the deficit by at least $1.2 trillion over the coming decade.

"If you look at the Democrats' position it was 'We have to raise taxes. We have to pass this jobs bill, which is another almost half-trillion dollars. And we're not excited about entitlement reform,' " Republican Jon Kyl of Arizona said in a combative interview on NBC's "Meet the Press."

Fanning out to the sets of the Sunday morning talk shows, Democrats and Republicans blamed each other for a deepening impasse that has all but doomed chances for an accord. In a series of interviews, not a single panelist seemed optimistic about any last-minute breakthrough. Under the committee's rules, any plan would have to be unveiled Monday.

Democrats said that Republicans on the supercommittee were simply unwilling to move on tax increases that Democrats insist should be part of any package that emerges from the negotiations. And Republicans said Democrats' demands on taxes were too great, even in response to a scaled-back GOP offer made late last week.

"There is one sticking divide. And that's the issue of what I call shared sacrifice," said panel co-chair Sen. Patty Murray. "The wealthiest Americans who earn over a million a year have to share too. And that line in the sand, we haven't seen Republicans willing to cross yet," the Washington Democrat said on CNN's "State of the Union."

On Saturday, Republicans floated an offer smaller than a $644 billion GOP plan leaked to the media late last week, said a lawmaker directly familiar with the panel's work. It too was rejected. The lawmaker required anonymity because of the secrecy of the talks.

It looks like the lawmakers charged with cutting the federal budget deficit as part of a congressional "supercommittee" are ready to throw in the towel. NBC's Kelly O'Donnell reports.

The Republican co-chair of Congress' debt supercommittee offered a glum assessment of prospects for an agreement.

Texas Rep. Jeb Hensarling said "nobody wants to give up," but he also told "Fox News Sunday" that "the reality is to some extent starting to overtake hope." He said the panel's deadlock "was a failure in not seizing an opportunity."

The committee faces a Wednesday deadline. But members would have to agree on the outlines of a package by Monday to allow time for drafting and assessing by the Congressional Budget Office.

Panel members say they will be available for further talks Sunday in hopes of a final breakthrough and some last-minute offers on smaller deficit-cutting packages were possible. Also on the agenda is stage managing the group's disbandment.

Republicans are demanding changes in so-called entitlement programs such as Medicare and Medicaid while Democrats are insisting on tax increases on the wealthy.

Over the past couple of weeks, the two sides have made a variety of offers and counter-offers, starting with a more than $3 trillion plan from Democrats that would have increased tax revenues by $1.3 trillion in exchange for further cuts in agency budgets, a change in the measure used to calculate cost-of-living increases for Social Security beneficiaries, and curbs on the growth of Medicare and Medicaid.

Republicans countered with a $1.5 trillion plan that included a potential breakthrough ? $250 billion in higher taxes gleaned as Congress passes a future tax reform measure. The plan was trashed by Democrats, however, who said it would have lowered tax rates for the wealthy too far while eliminating tax breaks that chiefly benefit the middle class.

Most recently, Republicans forwarded a smaller, face-saving $644 billion offer comprised of $543 billion in spending cuts, fees and other non-tax revenue, as well as $3 billion in revenue from closing a special tax break for corporate purchases of private jets. It also assumed $98 billion in reduced interest costs.

On Saturday, Republicans floated an even smaller, unspecified offer, said a lawmaker directly familiar with the panel's work. It too was rejected. The lawmaker required anonymity because of the secrecy of the talks.

Officials familiar with the offer said it would save the government $121 billion by requiring federal civilian workers to contribute more to their pension plans, shave $23 billion from farm and nutrition programs and generate $15 billion from new auctions of broadcast spectrum to wireless companies.

Democrats said the plan was unbalanced because it included barely any tax revenue.

"Our Democratic friends are unable to cut even a dollar in spending without saying it has to be accompanied by tax increases," Kyl said.

"We are unaware of any Democrat offer that didn't include at least $1 trillion tax increase on the American economy," Hensarling said.

Failure to reach agreement would trigger automatic across-the-board spending cuts to a wide variety of domestic programs and the Pentagon budget, starting in January of 2013. But both Defense Secretary Leon Panetta and many lawmakers say this automatic sequester would impose devastating cuts at the Pentagon.

"I hope it will be changed," Hensarling said. "Panetta said that cuts of that magnitude would hollow out our national defense."

Supercommittee member Sen. John Kerry says that the Democratic members of the deficit-cutting committee have "put every single sacred cow on the table."

Supercommittee member, Republican Whip Sen. Jon Kyl, said that there's a way to avoid "draconian" cuts "if there's good will on both sides" of the aisle.

?

Source: http://nbcpolitics.msnbc.msn.com/_news/2011/11/20/8911510-deficit-supercommittee-on-the-brink-of-failure

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Sunday, November 20, 2011

Americans going for 4th straight win (AP)

MELBOURNE, Australia ? The Americans have set off in their bid to win a fourth straight Presidents Cup in gorgeous weather and before a massive gallery at Royal Melbourne.

Even with Tiger Woods winning only one point, the Americans had a 13-9 lead over the International team going into the 12 singles matches. They need to win five of them to keep the cup.

Webb Simpson led off for the Americans against K.T. Kim.

The feature matches are Phil Mickelson against Adam Scott ? Mickelson doesn't like caddie Steve Williams, either ? and Woods facing Aaron Baddeley.

An International win would match the largest comeback in any team competition. The Americans also came from four points down to win the 1999 Ryder Cup.

THIS IS A BREAKING NEWS UPDATE. Check back soon for further information. AP's earlier story is below.

MELBOURNE, Australia (AP) ? So much about this Presidents Cup resembles the last time it was played at Royal Melbourne, from the sudden drop in temperatures to Tiger Woods winning only one point to a final day that holds so little drama.

The difference is the team on the verge of hoisting the gold cup.

The Americans built a big lead Saturday morning in the foursomes matches, with Woods finally rewarded with a point, then turned back a rally from the International team in the worst of the weather in the afternoon by capturing the final two matches.

"We needed those two points really bad," U.S. captain Fred Couples said. "And they got them for us."

Hunter Mahan delivered the most emotional moment of the week, holing a 20-foot birdie putt on the 17th right after Jason Day charged up the Australian crowd with an even longer birdie putt which he celebrated as if the match would be extended. Instead, Mahan and Bill Haas had a 2-and-1 win.

Moments later, Jim Furyk finished off the wild day with a clutch bunker shot on the 16th hole, and Nick Watney secured a par on the final hole for a 1-up decision over Adam Scott and Ernie Els that changed everything.

Those last two wins gave the Americans a 13-9 lead going into the 12 singles matches Sunday, a deficit from which no team has recovered in the 17-year history of this tournament.

The largest rally in any team event was when the Americans came from four points down to win the 1999 Ryder Cup. International captain Greg Norman didn't wag his finger and say he had a good feeling about this, as Ben Crenshaw did at Brookline.

He wasn't giving up, either, nor was his team.

"It's going to have to be a remarkable day tomorrow," Scott said. "But we have a shot. That's all we can ask for. It's not over."

The only time the International side has won this event was at Royal Melbourne in 1998, when it had a nine-point lead going into the Sunday singles and the cup was won as breakfast was still being served.

Woods was 1-3 that year going into the final day, only he wasn't alone. None of the Americans played well, leading to their worst loss ever in any team competition.

Woods finally put up a point Saturday morning in foursomes with Dustin Johnson. It wasn't pretty, but they forged ahead with a few pars and Woods ended the match by rolling in a 25-foot birdie putt. In the afternoon, Woods couldn't buy a putt. Despite putting for birdie on every hole ? only one of those from off the green ? he missed nine putts from about 15 feet and closer.

That included the 18th hole, when he missed a putt for a halve, and K.T. Kim knocked in a 6-foot par to give him and Y.E. Yang their first win of the week.

"It's all about making putts in match play, and we didn't do that," Woods said. "It just one of those things where that's how it all turns out. But hey, right now we've got a nice lead. And hopefully, tomorrow we can get the four-and-a-half points we need."

Webb Simpson will lead off the singles session against Kim, with Woods in the 11th spot against Aaron Baddeley.

The International team, which has won the Presidents Cup only once since it began in 1994, was hopeful that being in Australia would lead to another win, just like in 1998. Back then, it got plenty of help from its local players. With five Australians on this year's team, it hasn't worked out that way.

Robert Allenby, a captain's pick, was the only player on either side to not win a point. Scott is 1-3, while Baddeley and Day have faltered on the back nine throughout the week. Geoff Ogilvy is the only Australian with a winning record, as he and K.J. Choi won a tight match Saturday afternoon against Matt Kuchar and Steve Stricker.

The Americans continue to dominate the foursomes matches, as they have the last three years with a combined 25 1/2-7 1/2 margin. Most peculiar about this day, however, was the weather.

It started with a warm breeze and occasional rain. It ended in a steady rain, temperatures that plunged into the high 50s and a wind out of the opposite direction from when the day started.

"I've been coming to Melbourne for quite a few years," said Els, who teamed with Ryo Ishikawa for the International's only point in the morning foursomes. "I've played the north breeze and the southwesterly. But today was quite amazing. It blew from the north, and then it turned around and came from the south. We've had it all this week.

"Yesterday it was rock hard ... and today it was almost blowing like in Scotland."

The stars of the American team have been Furyk and Phil Mickelson, who have yet to lose a match. Furyk and Mickelson were 3-0 as a team until Couples sat Mickelson out Saturday afternoon, ending his streak of 32 consecutive matches played in this event, dating to the first session in 1998.

Furyk teamed with Watney and watched the Presidents Cup rookie hole one big putt after another.

"I felt like we went through about three different seasons today," Furyk said. "It was a tough day and a long day for those who played 36, and this morning was big for us to go 4-1 in five matches. And we hung on this afternoon, getting a point in those last two matches. We put ourselves in good position and have to come out firing tomorrow."

Retief Goosen and Charl Schwartzel handed Simpson and Bubba Watson their first loss of the week in the opening foursomes match in the afternoon. Even though the Americans rallied, it was the first time they had lost a session since singles in 2007 at Royal Montreal.

It still wasn't enough for them to lose control. In wild weather, the Americans kept their big lead.

Source: http://us.rd.yahoo.com/dailynews/rss/sports/*http%3A//news.yahoo.com/s/ap/20111119/ap_on_sp_go_su/glf_presidents_cup

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Cricket World Mourns Passing of South Africa?s Basil D'Oliveira

Test cricket legend Basil D'Oliveira has died at the age of 80.

Nicknamed ?Dolly,? D?Oliveira suffered from Parkinson?s disease and his health had been in decline for several years.

The former England all-rounder was born in South Africa, but emigrated to the United Kingdom in 1960 due to the lack of opportunities for non-white cricketers in his native country.

In honor of D?Oliveira, South African and Australian cricketers stood in silence for one minute before the start of the third day of the second and final Test at the Wanderers Stadium, in Johannesburg on Saturday.

South African batsmen Graeme Smith and Jacques Rudolph wore black armbands in tribute to D?Oliveira.

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By 1968, after eight years rising through the ranks of English cricket, D?Oliveira was at the center of an international controversy when, as a member of the England squad scheduled to tour South Africa, the refusal by the National Party to accept his presence led to a cancellation of the tour. The Pretoria government has classified the mixed-race D?Oliveira as a ?Cape Coloured.?

This incident led to South Africa?s increasing isolation in the global sporting world ? a prohibition that would last until the fall of Apartheid in the early 1990s.

Over his career, D'Oliveira played county cricket for Worcestershire from 1964-80 and represented England in 44 Tests, scoring 2,484 runs.

Cricket South Africa [CSA] chief executive Gerald Majola praised D?Oliveira

"He was a man of true dignity and a wonderful role model as somebody who overcame the most extreme prejudices and circumstances to take his rightful place on the world stage," he said in a statement.

"His memory and inspiration will live on among all of us. On behalf of the CSA family I would like to convey our sympathies to his family and salute them on a life well lived."

Mac Maharaj, President Jacob Zuma?s spokesman and a former anti-apartheid activist who was imprisoned with Nelson Mandela on Robben Island told media: ?[D?Oliveira?s] rejection from South Africa demonstrated the intransigence of the apartheid government and the open arms of the world to those who fought against apartheid in all of its forms. Basil had to make his life in cricket by leaving his birthplace.?

Maharaj added: ?The British gave him a home when apartheid South Africa rejected him. We heard the news about England pulling out of the South Africa tour in Robben Island. Basil?s stand confirmed the justness of our cause and reinforced our determination. It was really very heartening and an inspiration to us. Our attachment to Basil grew because he became a symbol of the struggle.?

In January 2000, South African cricket honored D?Oliveira by naming him among the nominees for South African Cricketer of the Century.
Ironically, the D'Oliveira Trophy is now the prize handed out to the winner of Test Series when England plays South Africa.

Milton Nkosi, BBC correspondent in Johannesburg, wrote: ?D'Oliveira was a man who proved the doctrine of racial prejudice wrong. [He] shook the very foundations of apartheid racist theory. When the white minority regime said black people were not fit to play alongside their white counterparts, Basil displayed an amazing talent for the sport. The Pretoria government's refusal in 1968 to allow him to play in a Test series cranked up the anti-apartheid call for a sports ban. Ironically, D'Oliveira was not being barred from playing for his country of birth -- he was deprived from playing for England, who had taken him in after he was shown no appreciation at home. The tour was cancelled and consequently the sporting world was galvanized to boycott apartheid South Africa.?

Nkosi added: "The circumstances surrounding his being prevented from touring the country of his birth with England in 1968 led directly to the intensification of opposition to apartheid around the world and contributed materially to the sports boycott that turned out to be an Achilles heel of the apartheid government. Throughout this shameful period in South Africa's sporting history, Basil displayed a human dignity that earned him worldwide respect and admiration.

Professor Andre Odendaal, author of The Story of an African Game, also praised D?Oliveira.
?Any young South African who loved cricket and sport knew about him and had all sorts of opinions about it,? he told reporters.

?What he did changed the world that South Africans knew, it was a defining moment, the beginning of the change in balance of power in South Africa. Everyone now says they were against apartheid but the cricket establishment was working with the government to keep blacks out.?

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Source: http://au.ibtimes.com/articles/252615/20111120/south-africa-cricket-basil-d-oliveira-london.htm

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Google+ has third biggest week since start

By Suzanne Choney

Social networking site Google+ recorded its third biggest week last week, with more than 6.8 million total U.S. visits, according to Hitwise.

The site launched last summer to an invite-only crowd. Its previous top two weeks were the week ending Sept. 24, when Google+ opened to all users, and the week after that.

Live Poll

Facebook or Google+?

  • 168259

    Sticking with Facebook. And that's that.

    26%

  • 168260

    Using both; like them for different reasons.

    26%

  • 168261

    Have ditched Facebook for G+.

    20%

  • 168262

    Getting ready to boot one or both; tired of social networking.

    28%

VoteTotal Votes: 284

Why the sudden boon? Mashable points to Google's recent introduction of "brand" pages on Google+?? which lets companies have their own pages, just as they do on Facebook ? well as the continuing addition of features, such as letting users rate images +1.

Google+ has had its ups and downs since it began. But recent signs are definitely on the "plus" side.

Hitwise director of research Heather Dougherty, on the company's blog, points to a few factors: Google+ "benefits from other Google properties for referral traffic. Among the top ten referral sources, eight are Google properties and accounted for 73 percent off all upstream traffic last week, up from 65 percent during the peak week of Sept. 24."

As "another positive sign," she cites the increasing number of returning visitors to Google+. "The average of the first two weeks of November versus the same time in October shows the share of returning visitors to the Google+ site increased 18 percent. Last week, 74 percent of the traffic to Google+ was from returning visitors, suggesting that Google+ users are returning to interact and engage with their networks (aka circles)."

Is Google+ starting to run "circles" around Facebook? What do you think? Let us know by voting in our poll.

Related stories:

Check out Technolog, Gadgetbox, Digital Life and In-Game on?Facebook,?and on Twitter, follow Suzanne Choney.

Source: http://technolog.msnbc.msn.com/_news/2011/11/17/8860943-google-has-third-biggest-week-since-start

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